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- In a study on consumption of aloe in rats and tilapia ( with no separation of gel from aloin ), significant negative health effects were found, including normocytic normochromic anaemia ( low red blood cell count, but normal cells ), hypoproteinaemia, and high AST levels.
- Aloin is usually prepared by extraction from aloe latex ( the term " Cape aloe " also refers to the dried latex of the leaves of several species of the " Aloe " genus, especially " A . ferox " [ Blumenthal, 1998 ] ), the bitter yellow exudate that seeps out from just underneath the skin of aloe leaves.
- In May 2002, the U . S . Food and Drug Administration ( FDA ) issued a ruling that aloe laxatives are no longer generally recognized as safe ( GRAS ) and effective, meaning that aloin-containing products are no longer available in over-the-counter drug products in the United States, because they may be carcinogenic and more data is needed to establish otherwise.
- "' Aloin "', also known as "'barbaloin "', is a bitter, yellow-brown colored compound noted in the exudate of at least 68 " Aloe " species at levels from 0.1 to 6.6 % of leaf dry weight ( making between 3 % and 35 % of the total exudate ) ( Groom & Reynolds, 1987 ), and in another 17 species at indeterminate levels [ Reynolds, 1995b ].