oxazolidinone造句

• A widely used method is the Evans'acyl oxazolidinone method.
• The oxazolidinone auxiliary is also conveniently cleaved under the hydrogenation conditions.
• The Z enolate was created to avoid the allylic strain with oxazolidinone.
• The absolute stereochemistry is then determined by the chirality of the oxazolidinone.
• ,linezolid is the only oxazolidinone antibiotic available.
• The synthesis of fragment A, alkyl iodide, applied the Evans'acyl oxazolidinone method.
• One of the things they did was reacting an oxazolidinone with the activated aldehyde chloral in an aldol addition:
• Structure activity relationships led to the development of several subclasses of oxazolidinone derivatives, with varying safety profiles and antimicrobial activity.
• Rivaroxaban bears a striking structural similarity to the antibiotic linezolid : both drugs share the same oxazolidinone-derived core structure.
• "' Posizolid "'is an oxazolidinone antibiotic under investigation by AstraZeneca for the treatment of bacterial infections.
• It's difficult to see oxazolidinone in a sentence. 用oxazolidinone造句挺難的
• Examples of chiral auxiliaries include, Evans chiral oxazolidinone auxiliaries ( for asymmetric aldol reactions ) pseudoephedrine amides and tert-butanesulfinamide imines.
• The ketene formation during the deprotonation process for substrates possessing Evans'oxazolidinone is also a main side reaction for the related alkylation reactions.
• In the case of the Evans'method, the chiral auxiliary appended is an oxazolidinone, and the resulting carbonyl compound is an imide.
• Tedizolid is a second-generation oxazolidinone derivative that is 4-to-16-fold more potent against staphylococci and enterococci compared to linezolid.
• The most-general method of asymmetric pyridine hydrogenation is actually a heterogeneous method, where asymmetry is generated from a chiral oxazolidinone bound to the C2 position of the pyridine.
• The anticoagulant rivaroxaban ( Xarelto ) bears a striking structural similarity to linezolid; both drugs share the oxazolidinone pharmacophore, differing in only three areas ( an extra ketone and chlorothiophene, and missing the fluorine atom ).
• In the syn-selective reactions, both enolization methods give the " Z " enolate, as expected; however, the stereochemical outcome of the reaction is controlled by the methyl stereocenter, rather than the chirality of the oxazolidinone.
• [Until 2000 ? ] Glycopeptides used to be the last effective line of defense for cases of MRSA, however several newer classes of antibiotics have proven to have activity against MRSA, including, in 2000, linezolid of the oxazolidinone class, and in 2003 daptomycin of the lipopeptide class.
• A new class of antibiotics, oxazolidinones, became available in the 1990s, and the first commercially available oxazolidinone, linezolid, is comparable to vancomycin in effectiveness against MRSA . Linezolid resistance in " S . aureus " was reported in 2001, but infection rates have been at consistently low levels and in the United Kingdom and Ireland, no resistance was found in staphylococci collected from bacteremia cases between 2001 and 2006.